Phosphorylation of MAP65-1 by Arabidopsis Aurora Kinases Is Required for Efficient Cell Cycle Progression1[OPEN]
نویسندگان
چکیده
Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium (J.B., A.K.W., E.M., K.K., M.N., L.D.M., N.G., D.I., T.B., D.V.D.); Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (J.B., A.K.W., E.M., K.K., M.N., L.D.M., N.G., D.V.D., D.I., T.B.); Laboratoire de Physiologie Cellulaire et Végétale, Institut de Recherches en Technologies et Sciences pour le Vivant, UMR5168, Centre National de la Recherche Scientifique/Commissariat à l’Énergie Atomique et aux Énergies Alternatives/Institut National de la Recherche Agronomique/Université Joseph-Fourier, Grenoble, France (V.S.-M.; M.V.); Institut National de la Santé et de la Recherche Médicale, U836, F-38000 Grenoble, France (V.S.-M., M.V.); Structural Biology Research Center, VIB, 1050 Brussels, Belgium (C.C., P.T.); Structural Biology Brussels, Vrije Universiteit Brussels, 1050 Brussels, Belgium (C.C., P.T.); and Exploring the Dynamics of Proteomes Laboratoire Biologie à Grande Echelle, U1038 Institut National de la Santé et de la Recherche Médicale/ Commissariat à l’Énergie Atomique et aux Énergies Alternatives/Université Joseph-Fourier Institut de Recherches en Technologies et Sciences pour le Vivant/Commissariat à l’Énergie Atomique et aux Énergies Alternatives/Grenoble, F-38054 Grenoble Cedex 9, France (M.J.)
منابع مشابه
Phosphorylation of MAP65-1 by Arabidopsis Aurora Kinases Is Required for Efficient Cell Cycle Progression.
Aurora kinases are key effectors of mitosis. Plant Auroras are functionally divided into two clades. The alpha Auroras (Aurora1 and Aurora2) associate with the spindle and the cell plate and are implicated in controlling formative divisions throughout plant development. The beta Aurora (Aurora3) localizes to centromeres and likely functions in chromosome separation. In contrast to the wealth of...
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Cell division depends on the fine control of both microtubule dynamics and microtubule organisation. The microtubule bundling protein MAP65 is a ;midzone MAP' essential for the integrity of the anaphase spindle and cell division. Arabidopsis thaliana MAP65-1 (AtMAP65-1) binds and bundles microtubules by forming 25 nm cross-bridges. Moreover, as AtMAP65-1 bundles microtubules in interphase, anap...
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The Hippo pathway controls organ size and tumorigenesis by inhibiting cell proliferation and promoting apoptosis. KIBRA was recently identified as a novel regulator of the Hippo pathway. Several of the components of the Hippo pathway are important regulators of mitosis-related cell cycle events. We recently reported that KIBRA is phosphorylated by the mitotic kinases Aurora-A and -B. However, t...
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Meiotic progression in Xenopus oocytes, and all other oocytes investigated, is dependent on polyadenylation-induced translation of stockpiled maternal mRNAs. Early during meiotic resumption, phosphorylation of CPE-binding protein (CPEB) is required for polyadenylation-induced translation of mRNAs encoding cell cycle regulators. Xenopus Gef (XGef), a Rho-family guanine-exchange factor, influence...
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Yin Yang 1 (YY1) is a ubiquitously expressed and highly conserved multifunctional transcription factor that is involved in a variety of cellular processes. Many YY1-regulated genes have crucial roles in cell proliferation, differentiation, apoptosis, and cell cycle regulation. Numerous mechanisms have been shown to regulate the function of YY1, such as DNA binding affinity, subcellular localiza...
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